The Paleo Solution - Episode 389 - Robb & Nicki Q&A #3

Hey Folks!

We're back with another Q&A episode!

If you have a question for a future episode, especially questions for Tyler and Luis of KetoGains on the next Q&A, submit them here https://robbwolf.com/contact/submit-a-question-for-the-podcast/

 

Show Notes:

1. (2:49) 23 and Me
   Kristin says:
   Robb and Nicki!
   Loved the first q&a back! I wanted to ask an expansion on the FTO gene Polymorphism question. I my self also ran my 23andme data through FoundMYFitness as a Rhonda Patrick follower and I have the similar FTO well several FTO genes came up but also the PPAR alpha gene came up that I know is a big part of ketosis. My question is can I attempt and Keto diet and Ketosis with using mainly PUFA and MUFA and still achieve ketosis with this polymorphism or am I better off to not focus on achieving ketosis?Thank you for all that you put in the world I just received you Wired to Eat book and started reading it! Love it so far!Kristin

NOTES:

FTO: https://academic.oup.com/jn/article/142/5/824/4630756
Fat Mass and Obesity–Associated Gene
Evolutionary Advantage-STRONG tendency toward obesity. Powerful adaptation in ancestral environment.

Evolutionary advantage not specific to Thrifty gene hypothesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031802/pdf/yjbm_87_2_99.pdf

Susceptibility to obesity (and inflammation)
https://www.diva-portal.org/smash/get/diva2:406173/FULLTEXT01.pdf

Drivers towards energy efficiency...back side of this is constrained Energy Hypothesis:
https://journals.lww.com/acsm-essr/Fulltext/2015/07000/Constrained_Total_Energy_Expenditure_and_the.3.aspx

Game theory and energy balance: http://journals.sagepub.com/doi/full/10.1177/1550147717720792

PPAR Alpha: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1528-1167.2008.01840.x

Peroxisome proliferator-activated receptor alpha is a drug/fatty acid-activated transcription factor involved in the starvation response,

Other SNP’s like CPT-1

 

2. (16:45) Ketone IVs / Ketone Ringer
   Stijn says:
   Dear Robb,
   Dear Robb Wolf team,For years I've wondered about using ketone bodies in IVs at intensive care, in the same way that glucose solutions are used. I imagine there being less inflammation versus the glucose, and thus better recovery. Though the effect might be minimal in a non-keto-adapted person. Then I am skipping over the entire blue light issue from all the fluorescents at a hospital. I recently watched your talk at Paleo FX, "Ketogenic Diets for Traumatic Brain Injury Keeping the Baby with the Bathwater". In brief you mention ketone ringers in an acute setting, traumatic brain injury and research in Japan. Why not use ketone bodies at intensive care, or even other settings? Have you seen research on this? Here's how I thought about it: my dad was at the ICU after cardiac arrest, and I saw the glucose syringes. Then I thought about inflammation and ketones. And I remembered reading that heart muscle likes ketones. Maybe we can save more people with ketone IVs...Please share your thoughts. I'm also interested in the Japanese research on ketone ringers, if you can link that.Thank you very much.Be well,
   Stijn De Puydt

 

NOTES:
Ketone ringer solution-
https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/152165401753311780

MCT Keto diet: https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/152165401753311780

High glucose load negated benefits!!

 

3. (20:54) Monkfruit

G says:
Hi. Can you briefly give me the straight dope on Monkfruit? I heard it doesn't spike your blood glucose levels making it a good alternative to sugar. I'm also guessing it still triggers pleasure centers in your brain which can lead to craving sweets.
My girl wanted to know how does Monkfruit Maple Syrup differ from 100% Pure Maple Syrup?
Thank you for your time,
g
Notes: https://www.nature.com/articles/ijo2016225

Generally not a huge effect: https://www.nature.com/articles/ijo2016225

 

4. (24:07) Alternatives to the classic Norcal Marg
   Colin says:
   Hey Rob, I like that you are back to doing some Q&A's and Nicki did a good job being your cohost. Do miss the ever large and in charge Greg Everett's humor though, "how does gravel burn," classic. Anyways, what are your thoughts on a Bone Broth Bullshot in lieu of your Norcal Marg? Potential pro/cons? On a second note, what if you were to add some glycine to that Norcal M? Give just a little sweetness and I would think there are some potentially extra benefits to that addition.. After listening to Chris Masterjohn's panel discussion on glycine, that crossed my mind.  Curious on your take. Thanks for everything you are doing (Paleo, health, keto, sustainability, controversial truths, etc.). While you are winding the clock back a little, you should get the Kraken on and let him destroy some questions.

 

5. (27:44) Exercise induced HypoglycemiaGreg says:
   Robb, hoping to get your insight into a problem I am experiencing. Non-diagnosed Diabetic. 6'1", 200 pounds, athletic build. Blood sugar drops into 60-69 mg/dL during moderate-intense exercise with moderate hypoglycemia symptoms. Measuring glucose (morning fasting 105-120 mg/dL, 2 hr post-meal 120-130 mg/dL). Chewing gum during exercise helps modulate glucose levels but still seems like there should be a better solution. Grain consumption 1-3/week. Limited sugar intake. Water and coffee w/heavy cream primary liquid consumption. Adrenal labs (normal DHEA, high normal cortisol). Worried Keto diet may further exacerbate during exercise. Any insight is greatly appreciated.

 

6. (31:46) Adaptogens and Gut Microbiome adaption

Eric says:

Digging the return of your podcast and the new format!  I have a couple of question submissions….

• We interviewed folks live for the Meatcast at Expo West, and the most consistent “trend” everyone noted from the show was “adaptogens” – what are your thoughts on adaptogens?  Flash in the pan fad or the unicorn cure to cancer?  Surely it can’t be anything in between
• Does our gut microbiome have the ability to adapt/evolve as we age, or is it “locked in” at a certain age?  We hear often that our exposure to good bacteria as a child impacts our autoimmunity later in life.  Whats so critical about those childhood years?  Is it simply our ability to adapt declining as we age?

 

7. (38:53) Good workout regimen for novice?
   Joe says:
   Hi Robb & Nicki,Can you recommend a good resource for a workout regimen? Right now I do weight training circuits Monday, Wednesday, Friday. Cardio Tuesday and Thursday, usually one cardio session is an interval (3x 30 second all-out exertion on an elliptical and the rest of the 20 minutes at moderate pace). I do a circuit for 6 weeks, then just do cardio for a week then start a different circuit for the next 6 weeks. Etc.I'm currently doing alternate daily fasting on my circuit days. Good sleep, good energy. I'm just wondering about new/more efficient ways to mix up my workouts as I'm still following what I did circa the early 2000s.Thanks,
   Joe

 

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